Glycine cleavage system P-protein, N-terminal
<p>This family consists of glycine cleavage system P-proteins (<db_xref db="EC" dbkey="1.4.4.2"/>) from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex (<db_xref db="EC" dbkey="2.1.2.10"/> (GDC) also annotated as glycine cleavage system or glycine synthase. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor, carbon dioxide is released and the remaining methylamin moiety is then transferred to the lipoamide cofactor of the H protein. GDC consists of four proteins P, H, L and T [<cite idref="PUB00009491"/>]. The reaction catalysed by this protein is:</p><p> Glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2 </p>